- Claude Bernard -
“The joy of discovery is certainly the liveliest that the mind of man can ever feel”
When LUGEVI-II was first introduced to the specialized scientific community, the opinion was not favorable.
In fact, their report analysis expounded, briefly, a set of hemodynamic principles that concluded, after a brief physical-mathematical proof, that modification of the cardiovascular system as proposed was not possible because you could not manage Median Blood Pressure from an artery; secondly, it concluded that even, if it were possible to do so, said control would be below therapeutically useful levels.
The principle of conservation of energy and LUGEVI-II.
Since the biophysics of my invention is based on the Principle of Conservation of Energy, I could not understand how, if a substantial volume of liquid is subtracted from a closed circuit, as in the human circulatory system, this would not affect a substantial decrease in pressure in that circuit.
The rebuttal led us to a fruitful controversy, in which I stated that in the present absence of a cohesive mathematical model that would prove or disprove the biophysical bases of LUGEVI-II, it was preferable to demonstrate in practice whether the invention either was or was not feasible.
Paving the Way (3)
A New Hemodynamic Paradigm
To this end, I built a set of emulator devices (1), (2) of the invention in such a way that they could be used in animal testing to determine whether the functional hypotheses of LUGEVI-II were correct or not. In addition, we tried to establish whether substantial changes (over 20 mm Hg) in the Mean Arterial Pressure (MAP) of a subject were also possible. For all these purposes, the femoral artery was selected as a test site.